Welcome to our April research update! Getting involved with research is an important way to impact asthma and allergy treatments, education, and awareness.
This month, we are highlighting clinical trials, surveys, and news on:
Note: The links below will take you to external websites.
Clinical Trials
Exploring Asthma Research Takes Courage and Strength
A clinical study is a VALIANT step forward.
The VALIANT clinical research study is looking for participants who are 18 to 80 years of age with physician-diagnosed asthma for at least 12 months, have suffered exacerbations (attacks) during the past year, and are regularly taking certain inhaled medications to manage asthma symptoms.
To learn more about the VALIANT study (study number: UPB-CP-04), please ask your doctor.
Sponsored by Upstream Bio, Inc.
Research Study for Black Teens with Asthma
KDH Research & Communication (KDHRC), a research organization in Atlanta, Georgia, is seeking input on the Personalized Approach To Habits – Sleep (PATH-S) app prototype. PATH-S will use casual gaming and intermittent reinforcement techniques to encourage teens to adopt and persist with personalized habits to improve sleep.
After a 90-minute Zoom interview, teens will receive a $100 incentive for participating. If you have any questions, please contact Morgan Fleming at mfleming@kdhrc.com. If you are interested in participating, then sign up by visiting this link.
Sponsored by KDH Research & Communication
Eosinophilic Asthma Research Study Enrolling
We are seeking volunteers for a paid research study that seeks to improve the way we treat severe asthma. This new study seeks to evaluate the safety of the investigational drug dexpramipexole (also called “Dex”) and how well it works for the treatment of this chronic condition.
Qualified participants must:
- Be 18 years and up
- Have a physician diagnosis of asthma at least a year ago
- Must be taking at least 1 medium to high dose maintenance inhaler daily, with another asthma medication
- Have had at least 2 asthma exacerbations requiring treatment with steroids in the past year
Participants will be compensated for time and travel for visits, and study-related doctor’s visits and study assessments are at no cost to you.
Discover new ways to breathe easier and live better.
Sponsored by Science37
Would You Like to Participant in a Nasal Polyp Clinical Study?

Have you been diagnosed with chronic rhinosinusitis with nasal polyps (CRSwNP) and your symptoms not well controlled with standard available treatments? If so, this clinical study may be looking for participants like you.
This clinical study is called Duet ACT18207. It is being done to test an investigational study drug, lunsekimig, to see if it is safe and effective as a treatment for CRSwNP. This is an injectable solution and patients who enroll will either receive lunsekimig or placebo injections every 4 weeks during the 6 months of the study treatment period.
Sponsored by Sanofi
Latest Asthma and Allergy News
Asthma
Differences in Asthma Care Cost Barriers by Insurance Status
Health insurance plays a big role in whether someone with asthma can afford their medicines and get the care they need. A recent study looked at how insurance affects the cost barriers of asthma care. Researchers compared costs for people with full-year insurance to costs for people with little or no coverage using 2019–2021 data on nearly 26,000 people with asthma.
While most (86%) people had full insurance, people with partial or no coverage had more issues with cost. Nearly half of the people had trouble paying for care, compared to about 11% of fully insured people with asthma.
Even with full insurance, some groups struggled more. Non-Hispanic Black people with asthma were almost twice as likely as White people to have cost issues for primary care. Women had more trouble affording asthma medicine than men.
For fully insured patients, older age, higher income, and longer time since symptoms helped reduce costs. People who recently went to the emergency room or stayed in the hospital were twice as likely to have trouble affording care.
The study shows that while uninsured people face greater challenges, many fully insured people also struggle with costs. Targeted support is needed to improve asthma care access for everyone.
Awareness of Wildfire Smoke Among U.S. Adults with and without Asthma
Each year, wildfires rage across the United States. The smoke from wildfires affects air quality and can make asthma symptoms worse. A recent study looked at how aware adults in the U.S. are of wildfire smoke in their area, comparing people with and without asthma. To compare awareness, the researchers also matched people's ZIP codes with wildfire smoke levels over the previous year.
Almost all (98%) respondents lived in areas affected by at least 1 day of medium or heavy wildfire smoke. They had, an average of 16 days of major smoke. But, only 19% of adults were aware of the wildfire smoke.
People with asthma were more likely to notice wildfire smoke than people without asthma, especially in areas with more or heavier smoke. Still, awareness was low overall.
The findings show that many people may not notice when wildfire smoke is in the air. This suggests a need for better public education about wildfire smoke and its health risks.
Insect Sting Allergy
Cholesterol Medicines May Raise Risk of Severe Allergic Reactions to Insect Stings
A recent study found that people who takemedicines to lowercholesterol, also called lipid-lowering medications (LLM), may be at higher risk for severe allergic reactions to insect stings. These medicines help lower cholesterol,but may also reduce a natural substance in the body that helps control allergic reactions. This iscalled PAF-AH. With less PAF-AH, allergic reactions might be more serious.
The researchers looked at medical records of 730 people in the U.S. and Canada from 2010 to 2023. About 12% of them were taking cholesterol medicine. Of all thepeople, 27% had severe reactions to insect stings. But amongpeopletaking cholesterol medicine, 44% had severe reactions. After considering other health conditions, the researchers found that people taking thesemedicineswere almosttwo timesas likely to have a severe reaction.
This is the first study to showa real-worldlinkand suggests doctors should be aware of this possible risk.But,more research is needed on this topic. Also,people should not stop taking cholesterol medicine without talking to their doctor.These medicines are important for heart health.
Topical Steroid Withdrawal (TSW)
New Diagnostic Criteria for Topical Steroid Withdrawal
Steroid medicines that you put on your skin (topical) are a common treatment for eczema. But, using them for a long time and then stopping can cause a condition called topical steroid withdrawal, or TSW. Like eczema, TSW causes symptoms like redness, burning, and itching.
Recently, researchers at the National Institutes of Health (NIH) found that topical steroid withdrawal (TSW) is a separate condition from eczema. In their study, the researchers found that people with TSW had high levels of a compound called NAD+. NAD+ is a form of vitamin B3. Too much can cause skin inflammation. Using skin cells and mice, they showed that blocking NAD+ could help reduce symptoms. In a small study, people with TSW who took medicines that block NAD+ production felt better after a few months.
Using this information, the researchers also created guidelines to help doctors better recognize and diagnose TSW. This research may lead to better treatments. But more studies are needed to fully understand the condition and its causes.
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