COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?

doi:10.1111/bjd.19804

. 2021 May;184(5):970-971.

doi: 10.1111/bjd.19804. Epub 2021 Feb 18.

COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?

R Gianotti¹, M Barberis², G Fellegara³, C Galván-Casas⁴, E Gianotti⁵

Affiliations

¹ Dermatology Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Dermatopathology Dept. Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
² Department of Pathology, European Institute of Oncology IRCCS, Milan, Italy.
³ Pathology Unit CDI, Centro Diagnostico Italiano SpA, Milan, Italy.
⁴ Department of Dermatology, Hospital Universitario de Móstoles, Rey Juan Carlos University, Madrid, Spain.
⁵ Healthcare Investment Banking, Citigroup, London, UK.

PMID: 33410129
PMCID: PMC9619443
DOI: 10.1111/bjd.19804

COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?

R Gianotti et al. Br J Dermatol.2021 May.

. 2021 May;184(5):970-971.

doi: 10.1111/bjd.19804. Epub 2021 Feb 18.

Authors

R Gianotti¹, M Barberis², G Fellegara³, C Galván-Casas⁴, E Gianotti⁵

Affiliations

¹ Dermatology Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Dermatopathology Dept. Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
² Department of Pathology, European Institute of Oncology IRCCS, Milan, Italy.
³ Pathology Unit CDI, Centro Diagnostico Italiano SpA, Milan, Italy.
⁴ Department of Dermatology, Hospital Universitario de Móstoles, Rey Juan Carlos University, Madrid, Spain.
⁵ Healthcare Investment Banking, Citigroup, London, UK.

PMID: 33410129
PMCID: PMC9619443
DOI: 10.1111/bjd.19804

No abstract available

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Figures

**Figure 1**
(a) Large urticarial erythematous plaques on the arms. (b) Minichilblain pattern demonstrating both superficial and deep perivascular dermatitis. (c) Massive lymphocytic infiltration surrounding deep eccrine glands. Immunohistochemical investigations for SARS‐CoV‐2 nucleocapsid antigens showed a cuticular staining of the glomerular part of the eccrine glands (inset). (d) In the context of the tubuloglandular structures, RNA fluorescence *in situ* hybridization (FISH) shows clear, strong, red bar‐like signals. Further sections of the same samples were pretreated with RNase to avoid false‐positivity. The RNA‐FISH result was negative (inset).

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References

1. Gianotti R, Veraldi S, Recalcati S. et al. Cutaneous clinico‐pathological findings in three COVID‐19‐positive patients observed in the metropolitan area of Milan, Italy. Acta Derm Venereol 2020; 100:adv00124. - PMC - PubMed
1. Gianotti R, Coggi A, Boggio F, Fellegara G. Similarities in cutaneous histopathological patterns between COVID‐19‐positive and COVID‐19 high‐risk patients with skin dermatosis. Acta Derm Venereol 2020; 100:adv00249. - PMC - PubMed
1. Wang H, Li X, Li T. et al. The genetic sequence, origin, and diagnosis of SARS‐CoV‐2. Eur J Clin Microbiol Infect Dis 2020; 39:1629–35. - PMC - PubMed
1. Torrelo A, Andina D, Santonja C. et al. Erythema multiforme‐like lesions in children and COVID‐19. Pediatr Dermatol 2020; 37:442–6. - PMC - PubMed
1. Massoth LR, Desai N, Szabolcs A. et al. Comparison of RNA in situ hybridization and immunohistochemistry techniques for the detection and localization of SARS‐CoV‐2 in human tissues. Am J Surg Pathol 2021; 45:14–24. - PubMed

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[1] Gianotti R, Veraldi S, Recalcati S. et al. Cutaneous clinico‐pathological findings in three COVID‐19‐positive patients observed in the metropolitan area of Milan, Italy. Acta Derm Venereol 2020; 100:adv00124. - PMC - PubMed

[2] Gianotti R, Veraldi S, Recalcati S. et al. Cutaneous clinico‐pathological findings in three COVID‐19‐positive patients observed in the metropolitan area of Milan, Italy. Acta Derm Venereol 2020; 100:adv00124. - PMC - PubMed

[3] Gianotti R, Coggi A, Boggio F, Fellegara G. Similarities in cutaneous histopathological patterns between COVID‐19‐positive and COVID‐19 high‐risk patients with skin dermatosis. Acta Derm Venereol 2020; 100:adv00249. - PMC - PubMed

[4] Gianotti R, Coggi A, Boggio F, Fellegara G. Similarities in cutaneous histopathological patterns between COVID‐19‐positive and COVID‐19 high‐risk patients with skin dermatosis. Acta Derm Venereol 2020; 100:adv00249. - PMC - PubMed

[5] Wang H, Li X, Li T. et al. The genetic sequence, origin, and diagnosis of SARS‐CoV‐2. Eur J Clin Microbiol Infect Dis 2020; 39:1629–35. - PMC - PubMed

[6] Wang H, Li X, Li T. et al. The genetic sequence, origin, and diagnosis of SARS‐CoV‐2. Eur J Clin Microbiol Infect Dis 2020; 39:1629–35. - PMC - PubMed

[7] Torrelo A, Andina D, Santonja C. et al. Erythema multiforme‐like lesions in children and COVID‐19. Pediatr Dermatol 2020; 37:442–6. - PMC - PubMed

[8] Torrelo A, Andina D, Santonja C. et al. Erythema multiforme‐like lesions in children and COVID‐19. Pediatr Dermatol 2020; 37:442–6. - PMC - PubMed

[9] Massoth LR, Desai N, Szabolcs A. et al. Comparison of RNA in situ hybridization and immunohistochemistry techniques for the detection and localization of SARS‐CoV‐2 in human tissues. Am J Surg Pathol 2021; 45:14–24. - PubMed

[10] Massoth LR, Desai N, Szabolcs A. et al. Comparison of RNA in situ hybridization and immunohistochemistry techniques for the detection and localization of SARS‐CoV‐2 in human tissues. Am J Surg Pathol 2021; 45:14–24. - PubMed

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COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?

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COVID-19-related dermatosis in November 2019: could this case be Italy's patient zero?

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