The aim of this study is to investigate the chronic effect of some cement components on the content of ions in different brain areas in adult male albino mice. It is clear that chronic intraperitoneal administration of 0.0013 mg/g aluminum ion caused a significant increase in aluminum, calcium and sodium ions and significant decrease in iron ions, the chronic intraperitoneal administration of 0.00065 mg/g iron caused a significant increase in iron, calcium, and sodium ions but No significant change in potassium and aluminum ions. Chronic intraperitoneal administration of 0.0013 mg/g silicon caused no significant change in calcium, potassium, sodium, aluminum and iron. Chronic intraperitoneal administration of 0.0013 mg/g aluminum, 0.0013 mg/g silicon and 0.00065 mg/g iron, respectively, --using separating time interval 30 min between each--caused a higher elevation in calcium, sodium, aluminum and iron concentrations than the elevation in other groups and no significant change in potassium ions. This may be due to the elevation in glutamate which leads to increase in the intracellular of calcium concentration and the inhibition of membrane-bound Na(+), K(+), Ca(2+) ATPase activity which lead to cellular alterations and may be death. So long-term exposure to cement components as environmental pollutants may lead to neurodegenerative diseases.