Our community

We are a research organization dedicated to understanding the roots of disease and closing the gap between new biological insights and impact for patients.

Research

Ovarian cancer cells overexpress high levels of the phosphate importer protein SLC34A2 (red) which pumps phosphate into a cell and leaves it vulnerable to inhibiting phosphate export. Cell nuclei are shown in blue.

Cancer

The human heart has a diversity of cell types, including cardiomyocytes (green) and fibroblasts (yellow). DNA is stained blue.

Cardiovascular disease

An intact pancreatic islet treated with interferon alpha and gamma, and stained for HLA-1 (yellow), proinsulin (magenta), nuclei (cyan).

Diabetes

Infectious disease and the microbiome

Kidney

Kidney disease

Obesity - cells

Obesity

This image shows human neurons (in blue), with the C4 protein (in green) deposited on synapses.

Brain health

Rare disease

X-ray co-crystal structure of B52 compound (cyan) binding and inhibiting Cyclophilin D protein

Chemical biology and therapeutics science

Inside CDoT library

Drug discovery

Screenshot_8

Genome regulation, cellular circuitry, and epigenomics

T Regulatory Cells. Scanning electron microscope image of T regulatory cells (red) interacting with antigen-presenting cells (blue). T regulatory cells can suppress responses by T cells to maintain homeostasis in the immune system.

Immunology

Manhattan plot

Medical and population genetics

Transmission electron microscope image of a mitochondria.

Metabolism

Data sciences, math on a black board

Data sciences

CRISPR

Genetic perturbation

Genomics Platform Sequencers

Genomics

This visualization illustrates the morphological variation of the BBC021 dataset

Imaging

Metabolomics

Metabolomics

Mass spectrometer, Proteomics platform

Proteomics

Spatial technologies

Spatial technologies